Novel functions of the epigenetic cancer driver KMT2D
- Level
- Postgraduate
- Mode
- Full-time
- Subject
- Biological Sciences
- Location
- United Kingdom
- Next intake
- OCT 2026
Overview
KMT2D, previously also known as MLL2 in humans, is a histone 3 lysine 4 (H3K4) methyltransferase. It has attracted attention as it is within the top 10 most mutated genes in cancer genomes, as well as the main reason behind the congenital disorder Kabuki syndrome. Importantly, in contrast to other cancer genes, the functions of KMT2D have not been clearly established yet. It is believed that KMT2D works through methylating H3K4 in chromatin, a mark of active transcription, and facilitating enhancer mediated transcriptional activation.
English language requirements
| IELTS | 6.5 overall |
|---|
IELTS 6.5 overall (component minima vary by programme; see university English-language requirements)
Start dates
October 2026
Campus
- Birmingham, United Kingdom
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